Methods of Treating Diseases Using Inhibitors of Nucleoside Phosphorylases and Nucleosidases
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United States of America Patent
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Issued Date -
Apr 21, 2011
app pub date -
Feb 23, 2007
filing date -
Feb 24, 2006
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Abstract
The invention relates to treating a disease or condition in which it is desirable to inhibit 5′-methylthioadenosine phosphorylase (MTAP) and/or 5′-methylthioadenosine nucleosidase (MTAN). The invention particularly relates to the co-administration of 5′-methylthioadenosine (MTA), or a prodrug of MTA, with one or more MTAP/MTAN inhibitors. Included among the diseases treatable are prostate cancer and head and neck cancer.
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