Novel Gene Disruptions, Compostitions and Methods Relating Thereto

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20110097330A1
SERIAL NO

11722967

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO179, PRO181, PRO244, PRO247, PRO269, PRO293, PRO298, PRO339, PRO341, PRO347, PRO531, PRO537, PRO718, PRO773, PRO860, PRO871, PRO872, PRO813, PRO828, PRO1100, PRO1114, PRO115, PRO1126, PRO1133, PRO1154, PRO1185, PRO1194, PRO1287, PRO1291, PRO1293, PRO1310, PRO1312, PRO1335, PRO1339, PRO2155, PRO1356, PRO1385, PRO1412, PRO1487, PRO1758, PRO1779, PRO1785, PRO1889, PRO90318, PRO3434, PRO3579, PRO4322, PRO4343, PRO4347, PRO4403, PRO4976, PRO260, PRO6014, PRO6027, PRO6181, PRO6714, PRO9922, PRO7179, PRO7476, PRO9824, PRO19814, PRO19836, PRO20088, PRO70789, PRO50298, PRO51592, PRO1757, PRO4421, PRO9903, PRO1106, PRO1411, PRO1486, PRO1565, PRO4399 or PRO4404 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

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Patent Owner(s)

Patent OwnerAddress
LEXICON PHARMACEUTICALS INC2445 TECHNOLOGY FOREST BLVD 11TH FLOOR THE WOODLANDS TX 77381

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Clarke, Catherine Batac Conroe, US 1 22
Combs, Katherin E San Antonio, US 13 153
de, Sauvage Frederic J Foster City, US 74 640
Ding, Zhiyong Valhalla, US 24 106
Edwards, Joel Rancho Santa Margarita, US 22 105
Godowski, Paul Hillsborough, US 29 217
Horner, Allison Anne Byers Missouri City, US 7 50
Huang, Wenhu San Diego, US 8 80
Ketcherside, Lorelei Diane The Woodlands, US 1 22
Massey, Erin Marie Spring, US 11 135
Montgomery, Charles Jay, US 23 234
Payne, Bobby Joe The Woodlands, US 18 150
Peterson, Andrew San Francisco, US 32 307
Qian, Ni Nancy San Diego, US 6 52
Schrick, Jeffrey J Conroe, US 1 22
Shi, Zheng-Zheng Spring, US 27 244
Sparks, Mary Jean Corpus Christi, US 27 291
Stala, Joy Anne Santa Monica, US 13 153
Viator, Colleen M Katy, US 1 22
Vogel, Peter Spring, US 82 1675
Wilson, Deanna Grant San Mateo, US 2 22
Ye, Weilan Foster City, US 54 355
Yeh, Jung-Hua Belmont, US 3 23

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