LIPOPHILIC DIESTERS OF CHELATING AGENT FOR INHIBITION OF ENZYME ACTIVITY

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United States of America Patent

SERIAL NO

12855081

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Abstract

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The present invention relates to the use of lipophilic diesters of the chelating agent 1,2-bis(2 aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (BAPTA) for inhibition of proteolytic activities of certain metalloproteinases, calpain and TACEThe invention further relates to methods for preventing, treating or managing TACE-related diseases or disorders in mammals comprising administering to a mammal in need thereof, a pharmaceutical composition comprising a therapeutically effective amount of said lipophilic diesters of the chelating agent BAPTA.

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Patent Owner(s)

Patent OwnerAddress
D-PHARM LTDREHOVOT REHOVOT CENTRAL DISTRICT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Friedman, Jonathan Eduard Rehovot, IL 2 1
Kozak, Alexander Rehovot, IL 22 140
Reznitsky-Cohen, Dalia Nes Ziona, IL 4 3
STRIEM, Sarina Ganei Yohanan, IL 2 1

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