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Abstract

antibodies induced apoptosis of effector T cells. It is believe that this is the first cell culture technique that expands regulatory T cells while inducing the apoptosis of effector cells in the mixed lymphocyte population using binding partners for cell surface proteins immobilized on planar substrate. Because effector T cells are typically present in mixed populations of lymphocytes, effector T cells compete with regulatory T cells and typically overtake the cell culture. The disclosed methods decrease the population of effector cells allowing regulatory T cells to expand by at least 100, typically by 400 fold. The resulting cultures of regulatory T cells have less than about 20%, 15%, or 10% of effector T cells.

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First Claim