COMPOSITIONS AND METHODS FOR DIAGNOSING LATE-ONSET ALZHEIMER'S DISEASE

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United States of America Patent

SERIAL NO

12790045

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Abstract

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Genetic markers for late-onset Alzheimer's disease (AD) within the TRPC4AP gene locus are provided. The genetic markers include single nucleotide polymorphisms (SNPs) and haplotypes. Methods and kits for using the disclosed genetic markers to identify, or assist in the identification of, subjects as having late-onset AD, or as having an increased risk for developing late-onset AD are provided. In a preferred embodiment the genetic markers are one or more SNPs selected from the group consisting of rs1058003, rs3746430, rs3736802, rs6088677, rs6087660, rs4911460, rs6087664, rs13042358, rs6088692, rs6120816, rs1885119, rs2065108 and rs6088727, or haplotype: rs1058003_G: rs3746430_T: rs3736802_T: rs6088677_C: rs6087660_T: rs4911460_G: rs6087664_C: rs13042358_G: rs6120816_G: rs1885119_T.

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Patent Owner(s)

Patent OwnerAddress
MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE INC1120 15TH STREET AUGUSTA GA 30912

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Poduslo, Shirley North Augusta, US 1 0

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