Process for enantiomerically pure 8-Aryloctanoic acids as Aliskiren
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United States of America Patent
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Issued Date -
Jun 9, 2011
app pub date -
Oct 15, 2010
filing date -
Dec 7, 2009
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Abandoned
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Abstract
The present invention relates to a novel manufacturing process and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially rennin inhibitors such as Aliskiren. The invention describes a preparation of enantiomerically pure 8-aryloctanoic acids of general formula I from readily available key intermediate, chiral cis-diacid of formula II, aziridine of formula XI and a monocyclic compound of formula III.
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