COMBINED METHOD FOR PREDICTING THE RESPONSE TO AN ANTI-CANCER THERAPY
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United States of America Patent
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Issued Date -
Jun 16, 2011
app pub date -
May 20, 2009
filing date -
May 20, 2008
priority date (Note) -
Abandoned
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Abstract
The invention provides methods for predicting the response to a topoisomerase Ilα inhibitor therapy in an individual having cancer, wherein the methods comprise the steps of determining TIMP-I DNA aberration/TIMP-1 protein aberration in combination with determining DNA aberration in TOP2A/HER2 amplicon on chromosome 17q21 including TOP2A and HER2 or aberrations of TOP2A and ErbB2 protein expression. Further provided are methods of treating cancer by using said topoisomerase Ilα inhibitor therapy. The invention also comprises a kit for the application of the methods for predicting the response to a topoisomerase Ilα inhibitor therapy in an individual having cancer.
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