Neuroinvasion inhibitor

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 10717781
APP PUB NO 20110150869A1
SERIAL NO

12996162

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Abstract

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The present inventors discovered that neural invasion is suppressed by inhibiting IL-6 in a model for neural invasion of pancreatic cancer, and completed the present invention. The present inventors also demonstrated that: an IL-6 receptor is expressed in cells of human pancreatic cancer cell lines; and IL-6 enhances the chemotactic and migratory activities and intracellular signaling of pancreatic cancer cells; and thus pancreatic cancer can be treated by inhibiting IL-6. Furthermore, the present inventors found that neural invasion of human pancreatic cancer can be suppressed, from the results of administering IL-6 inhibitors to neural invasion model mice.

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Patent Owner(s)

  • NATIONAL CANCER CENTER; CHUGAI SEIYAKO KABUSHIKI KAISHA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Mitsunaga, Shuichi Chiba, JP 5 82
Ochiai, Atsushi Chiba, JP 59 170

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