SHIGA TOXIN B-SUBUNIT/CHEMOTHERAPEUTICS CONJUGATES
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United States of America Patent
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Issued Date -
Jun 23, 2011
app pub date -
Dec 18, 2007
filing date -
Dec 18, 2007
priority date (Note) -
Abandoned
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Abstract
The present invention relates to the use of a Shiga toxin B-subunit moiety as carrier for therapeutic agents, for example, anti-cancer agents such as anti-cancer agents that require intracellular uptake to exert their anti-cancer effects. In particular, the present invention provides conjugates comprising a Shiga toxin moiety covalently linked to an anti-cancer agent through a self-immolative spacer, and methods of using such conjugates to increase cellular uptake and/or specificity for cancer cells of the anti-cancer drug. Also provided are methods of treatment involving administration of such conjugates, and pharmaceutical compositions and kits useful for carrying out such methods of treatment.
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