US Patent Application No: 2011/0158,991

Number of patents in Portfolio can not be more than 2000

CYTOTOXIC AGENTS COMPRISING NEW MAYTANSINOIDS

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

New thiol and disulfide-containing maytansinoids bearing a mono or di-alkyl substitution on the α-carbon atom bearing the sulfur atom are disclosed. Also disclosed are methods for the synthesis of these new maytansinoids and methods for the linkage of these new maytansinoids to cell-binding agents. The maytansinoid-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.

Loading the Abstract Image... loading....

First Claim

See full text

all claims..

Related Publications

Loading Related Publications... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
IMMUNOGEN, INC.WALTHAM, MA103

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chari, Ravi VJ Newton, MA 49 42
Widdison, Wayne C Somerville, MA 25 88

Patent Citation Ranking

Forward Cite Landscape

  • No Forward Cites to Display

Full Text

 
loading....