US Patent Application No: 2011/0158,991

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CYTOTOXIC AGENTS COMPRISING NEW MAYTANSINOIDS

ALSO PUBLISHED AS: 8841425

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Abstract

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New thiol and disulfide-containing maytansinoids bearing a mono or di-alkyl substitution on the α-carbon atom bearing the sulfur atom are disclosed. Also disclosed are methods for the synthesis of these new maytansinoids and methods for the linkage of these new maytansinoids to cell-binding agents. The maytansinoid-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
IMMUNOGEN, INC.WALTHAM, MA97

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chari, Ravi VJ Newton, MA 50 66
Widdison, Wayne C Somerville, MA 26 108

Cited Art Landscape

Patent Info (Count) # Cites Year
 
IMMUNOGEN, INC. (4)
* 2004/0241,174 Drug conjugate composition 11 2004
* 7,276,497 Cytotoxic agents comprising new maytansinoids 20 2004
* 8,435,528 Cytotoxic agents comprising new maytansinoids 1 2007
* 8,198,417 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates and methods of making said conjugates 5 2007
* Cited By Examiner

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