US Patent Application No: 2011/0158,991

Number of patents in Portfolio can not be more than 2000

CYTOTOXIC AGENTS COMPRISING NEW MAYTANSINOIDS

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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New thiol and disulfide-containing maytansinoids bearing a mono or di-alkyl substitution on the α-carbon atom bearing the sulfur atom are disclosed. Also disclosed are methods for the synthesis of these new maytansinoids and methods for the linkage of these new maytansinoids to cell-binding agents. The maytansinoid-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
IMMUNOGEN, INC.WALTHAM, MA118

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
CHARI, Ravi VJ Newton, US 64 263
WIDDISON, Wayne C Somerville, US 24 259

Cited Art Landscape

Patent Info (Count) # Cites Year
 
IMMUNOGEN, INC. (16)
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* 5,416,064 Cytotoxic agents comprising maytansinoids and their therapeutic use 144 1992
* 6,333,410 Process for the preparation and purification of thiol-containing maytansinoids 90 2000
* 6,441,163 Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents 94 2001
* 6,716,821 Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same 78 2001
* 2004/0241,174 Drug conjugate composition 19 2004
* 7,374,762 Drug conjugate composition 13 2004
* 7,276,497 Cytotoxic agents comprising new maytansinoids 38 2004
* 7,301,019 Method for the preparation of maytansinoid esters 8 2006
* 7,514,080 Drug conjugate composition 12 2006
* 7,494,649 Drug conjugate composition 11 2006
* 7,501,120 Drug conjugate composition 11 2006
* 8,435,528 Cytotoxic agents comprising new maytansinoids 2 2007
* 8,198,417 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates and methods of making said conjugates 13 2007
* 8,012,485 Drug conjugate composition 5 2009
* 2011/0300,162 DRUG CONJUGATE COMPOSITION 2 2011
 
The United States of America as represented by the Secretary of Agriculture (1)
* 4,315,929 Method of controlling the European corn borer with trewiasine 76 1981
 
SMITHKLINE BEECHAM P.L.C. (1)
* 6,573,074 Methods for ansamitocin production 8 2001
 
GLAXOSMITHKLINE LLC (2)
* 6,570,024 Process and intermediates 7 2001
* 6,884,874 Process and intermediates 6 2003
 
ASTRAZENECA AB (1)
* 2005/0176,780 2,5-disubstituted 3-mercaptopentanoic acid 1 2004
* Cited By Examiner

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