METHODS FOR TREATMENT AND PREVENTION OF OTOTOXICITY BY siRNA
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United States of America Patent
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Issued Date -
Jun 30, 2011
app pub date -
Aug 13, 2007
filing date -
Aug 13, 2007
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Abandoned
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Abstract
The present invention relates to methods for reducing and/or preventing ototoxicity caused by an ototoxic agent, noise or head and/or neck radiation. It is also directed to a method for preventing or reducing generation of reactive oxygen species in the inner ear of a patient. The methods of the present invention include administering at least one siRNA directed against TRPV1 mRNA, NOX3 mRNA or a combination thereof.
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