Importance

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Abstract

A transdermal medicament patch includes a flexible substrate having a therapeutic face configured for releasable retention against the skin of a patient, a medicament matrix susceptible to permeation by medicament and secured to the therapeutic face of the substrate, and a return electrode secured to the therapeutic face spaced from the medicament matrix. The return electrode and the medicament matrix effect electrically conductive engagement with the skin of the patient when the substrate is retained thereupon. A power source is carried on substrate so electrically coupled between the medicament matrix and the return electrode as to cause iontophoretic migration of medicament from the medicament matrix into the skin of the patient. A dosage control circuit carried non-removably on said substrate limits to a predetermined medicament quantity the total medicament administered into the skin of the patient by iontophoretic migration during a predetermined therapy period.

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First Claim