SCREENING METHODS FOR HEAT-SHOCK RESPONSE MODULATORS
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United States of America Patent
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Issued Date -
Jul 7, 2011
app pub date -
Jun 3, 2009
filing date -
Jun 3, 2008
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Abstract
High-throughput methods are provided for quantitatively measuring the modulation of heat shock protein (HSP) expression in a cell by exposing the cell to at least one stress and measuring cellular stress responses. High-throughput methods for identifying modulators (activators or inhibitors) of HSP or HSF expression in a cell by treating the cell with an agent, such as a compound or composition, exposing the cell to a stress, and measuring responses of the cell to the stress in the presence or absence of the agent are also provided. Devices useful in performing high-throughput methods of the invention, and modulators identified using such methods, are also provided.
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