PROCESS FOR PREPARING PURIFIED DRUG CONJUGATES
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United States of America Patent
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Issued Date -
Jul 7, 2011
app pub date -
Dec 22, 2010
filing date -
Feb 11, 2005
priority date (Note) -
Abandoned
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Abstract
The invention provides processes for preparing a cell-binding agent chemically coupled to a drug. A first process comprises covalently attaching a linker to a cell-binding agent, an optional purification step, conjugating a drug to the cell-binding agent, a subsequent purification step, and optional holding steps. A second process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent, a subsequent purification step, holding steps, and optionally a tangential flow filtration (TFF) step.
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