Use of Oligonucleotides with Modified Bases as Antiviral Agents
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United States of America Patent
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Issued Date -
Jul 14, 2011
app pub date -
Nov 5, 2008
filing date -
Nov 5, 2007
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Abstract
The present invention relates to the use of oligonucleotides having modified nucleobases to inhibit gene expression and/or replication of viruses in a subject. The modified nucleobases may be mercapto-modified bases or hydroxy-modified nucleobases. It is contemplated that the oligonucleotides further comprise a nuclease complex which enhances anti-viral activity of the oligonucleotides.
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