Artificial corneal implant

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United States of America Patent

SERIAL NO

12928819

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Abstract

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A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a second network. The first network and the second network are based on biocompatible polymers. At least one of the network polymers is based on a hydrophilic polymer. The artificial cornea or implant has epithelialization promoting biomolecules that are covalently linked to the surface of the double network hydrogel using an azide-active-ester chemical linker. Corneal epithelial cells or cornea-derived cells are adhered to the biomolecules. The double network has a physiologic diffusion coefficient to allow passage of nutrients to the adhered cells.

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Patent Owner(s)

Patent OwnerAddress
BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY THE1705 EL CAMINO REAL PALO ALTO CA 94306

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Carrasco, Michael R Cupertino, US 4 146
Frank, Curtis W Cupertino, US 55 1942
Hartmann, Laura Berlin, DE 15 165
Hu, Yin Newark, US 13 192
Koh, Won-Gun Kyunggi Yongin, KR 6 146
Myung, David Santa Clara, US 68 1153
Noolandi, Jaan La Jolla, US 72 1573
Smith, Alan J Grass Valley, US 11 485
Ta, Christopher N Palo Alto, US 7 57

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