CISD2-Knockout Mice and Uses Thereof
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United States of America Patent
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app pub date -
Mar 7, 2011
filing date -
Oct 3, 2006
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Abstract
The present invention is related to a Cisd2 knockout mouse with phenotype comprising mitochondrial breakdown and dysfunction, wherein Cisd2 is defined as SEQ ID NO. 1. The present invention is also related to a mouse model of Wolfram Syndrome 2 (WFS2) disease consisting of a Cisd2 knockout mouse. The present invention is further related to a method for screening a candidate agent for preventing or treating WFS2 disease.
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