Methods and Compositions for Reducing Systemic Toxicity of Vectors
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United States of America Patent
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Issued Date -
Aug 4, 2011
app pub date -
Feb 13, 2006
filing date -
Feb 11, 2005
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Abandoned
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Abstract
A method for reducing leakage of a delivery formulation from a target tissue via a damaged blood vessel during and after administration of the delivery formulation is provided. The method includes the steps of: (a) providing a delivery formulation comprising a blocking agent and one or more vectors encoding one or more polypeptides, wherein the delivery formulation is in a liquid form; and (b) administering the delivery formulation to a target tissue in a subject, wherein the administering results in the viscosity of the blocking agent increasing to at least about 100 cP, whereby leakage of the delivery formulation from the target tissue either during or after administration of the delivery formulation is reduced.
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