Taxane- and taxoid-protein compositions

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United States of America Patent

PATENT NO 9333189
APP PUB NO 20110190204A1
SERIAL NO

13017173

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Compositions comprising a taxane or taxoid, such as paclitaxel, and a protein, such as albumin or a metal-transferrin, such as gallium-transferrin, can be prepared by combining an aqueous protein solution with a second solution containing the taxane or taxoid, a non-ionic surfactant, and an alcohol; adjusting the pH of the combined solutions to between about 7.9 and about 8.3; and purifying the pH-adjusted solution to remove solutes having a molecular weight less than 10,000 Da. Such compositions can be prepared that are substantially free of non-ionic surfactants, such as Cremophor EL, and are useful in the treatment of cancers, such as breast cancer.

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Patent Owner(s)

  • ONCBIOMUNE, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Elliott, Robert L Baton Rouge, US 20 245
Head, Jonathan F Baton Rouge, US 10 78

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