LACTATION-ASSOCIATED POLYPEPTIDES
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United States of America Patent
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Issued Date -
Aug 18, 2011
app pub date -
Aug 8, 2008
filing date -
Aug 8, 2007
priority date (Note) -
Abandoned
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Abstract
The invention relates to cDNA libraries obtained from Tammar wallaby (Macropus eugenii) mammary gland tissue at different times (including day 23 pregnancy, day 130 lactation, and day 260 lactation). Lactation-associated polypeptides were identified from these cDNA libraries, and bovine homologues of the wallaby proteins are also disclosed. The proteins have a range of activities including anti-apoptotic activity, pro- or anti-inflammatory activity, cathelicidin anti-microbial activity, induction of trefoil proteins (and protection of epithelial surfaces), increased cell proliferation, and induction of cell differentiation (and loss of pluripotency).
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