GLUTAMIC ACID DECARBOXYLASE (GAD) BASED DELIVERY SYSTEM
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United States of America Patent
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app pub date -
Apr 27, 2011
filing date -
May 23, 2000
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Abstract
The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding glutamic acid decarboxylase (GAD) to cells in the hippocampus, subthalamic nucleus of the basal ganglia, mesaphilia and thalamus.
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