Pharmaceutical compositions of selective factor Xa inhibitors for oral administration
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United States of America Patent
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Jul 28, 2015
Grant Date -
Sep 29, 2011
app pub date -
Mar 28, 2011
filing date -
Mar 26, 2010
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Abstract
The present invention provides pharmaceutical compositions for oral administration comprising a therapeutically effective amount of a selective factor Xa inhibitor or a pharmaceutically acceptable salt thereof and an enhancer, wherein the enhancer is a medium chain fatty acid or a salt, ester, ether, or derivative of a medium chain fatty acid and has a carbon chain length of from about 4 to about 20 carbon atoms. The present invention also provides a method for obtaining a reproducible bioavailability of selective factor Xa inhibitor in an object after oral administration comprising orally administering a pharmaceutical composition as described above.
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