SMART CONTRAST AGENTS FOR MRI IMAGING
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United States of America Patent
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Issued Date -
Oct 6, 2011
app pub date -
Dec 18, 2009
filing date -
Dec 19, 2008
priority date (Note) -
Abandoned
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Abstract
A contrast agent for MRI imaging includes: (a) one cyclodextrin, whose truncated-cone-shaped structure defines a central axis, a first and a second openings along the axis, (b) one paramagnetic element, located on the cyclodextrin axis, outside the structure and proximate to the first opening, (c) one or several coordination ligand(s) of the paramagnetic element which coordinate(s) the paramagnetic element, (d) one arm covalently bound to the cyclodextrin, proximate to the second opening, which is able to form an inclusion complex with the cyclodextrin.
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