US Patent Application No: 2011/0243,899

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Wnt Signaling Inhibitor Comprising Insulin-Like Growth Factor-Binding Protein

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Abstract

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Provided is a novel soluble factor that modulates morphogenesis and cell proliferation, such as cardiac development and/or cardiomyocyte differentiation. Specifically provided are: an inhibitor of Wnt signalling, comprising an insulin-like growth-factor-binding protein (IGFBP), the protein being binding to a Wnt receptor, and/or a polynucleotide encoding the protein; a medicament for prevention and/or treatment of a disease due to enhanced Wnt signalling, comprising the inhibitor of Wnt signalling, and a medicament for induction of cardiomyocyte differentiation; and a method for prevention and/or treatment of a disease due to enhanced Wnt signalling and a method of inducing cardiomyocyte differentiation, the methods each comprising using the inhibitor of Wnt signalling, and a cardiomyocyte, which is obtained by the method of inducing cardiomyocyte differentiation, and a use thereof.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITYCHIBA31

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Komuro, Issei Tokyo, JP 4 0
Shiojima, Ichiro - 1 0
Zhu, Weidong Fremont, CA 16 17

Cited Art Landscape

Patent Info (Count) # Cites Year
 
DAIICHI SANKYO COMPANY, LIMITED (1)
* 8,293,529 Method for inducing differentiation of pluripotent stem cells into cardiomyocytes 0 2007
 
DEPARTMENT OF VETERANS AFFAIRS (1)
* 2005/0148,509 Binding proteins as chemotherapy 2 2004
 
ES CELL INTERNATIONAL PTE LTD. (1)
* 2007/0204,351 Direct differentiation of cardiomyocytes from human embryonic stem cells 2 2006
 
NEW YORK UNIVERSITY (1)
* 2011/0034,381 Methods for Therapeutic Treatment of Benign Prostatic Hypertrophy (BPH) 0 2003
 
The Salk Institute for Biological Studies (1)
* 6,004,775 DNA encoding IGFBP-4 5 1993
 
ZymoGenetics, Inc. (1)
* 6,395,890 Nucleic acids encoding connective tissue growth factor homologs 0 1999
* Cited By Examiner

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