US Patent Application No: 2011/0243,899

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Wnt Signaling Inhibitor Comprising Insulin-Like Growth Factor-Binding Protein

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Abstract

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Provided is a novel soluble factor that modulates morphogenesis and cell proliferation, such as cardiac development and/or cardiomyocyte differentiation. Specifically provided are: an inhibitor of Wnt signalling, comprising an insulin-like growth-factor-binding protein (IGFBP), the protein being binding to a Wnt receptor, and/or a polynucleotide encoding the protein; a medicament for prevention and/or treatment of a disease due to enhanced Wnt signalling, comprising the inhibitor of Wnt signalling, and a medicament for induction of cardiomyocyte differentiation; and a method for prevention and/or treatment of a disease due to enhanced Wnt signalling and a method of inducing cardiomyocyte differentiation, the methods each comprising using the inhibitor of Wnt signalling, and a cardiomyocyte, which is obtained by the method of inducing cardiomyocyte differentiation, and a use thereof.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITYCHIBA32

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Komuro, Issei Tokyo, JP 4 0
Shiojima, Ichiro - 1 0
Zhu, Weidong Fremont, CA 14 15

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