METHOD OF SOLUBILIZING BIOLOGICALLY ACTIVE COMPOUNDS
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United States of America Patent
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Issued Date -
Oct 6, 2011
app pub date -
Sep 28, 2009
filing date -
Sep 26, 2008
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Abandoned
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Abstract
The invention describes a method of preparing lipid compositions by associating pH sensitive compounds which maybe weak acids, bases or amphoteric compounds with at least one ionisable or pH sensitive group and low water solubility into preformed and standardised lipid particles by pH manipulation. Drug association is carried out in situ by changing the pH of the aqueous medium to pH 6-8 wherein the compound spontaneously partitions into the lipid particles. Drug association may also be carried out by exploiting pH changes in the GI tract. The lipophilic compound is solubilised by the lipid particles and may be used as such for in-vitro and pharmacokinetic assessments or processed for oral, parenteral or topical therapy.
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