Adjuvant combinations of liposomes and mycobacterial lipids for immunization compositions and vaccines

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 8241610
APP PUB NO 20110250224A1
SERIAL NO

13083385

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Abstract

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The present invention provides a vaccine adjuvant consisting of a combination of a surfactant i.e. dimethyldeoctadecylammonium-bromide/chloride (DDA) and a lipid extract from Mycobacterium bovis BCG. The total lipid extract contains both apolar lipids, polar lipids, and lipids of intermediate polarity of which the apolar lipids were found to induce the most powerful immune responses. The total lipids may be extracted with chloroform/methanol and re-dissolved in water before the addition of surfactant. This preparation may be used to induce prominent cell-mediated immune responses in a mammal in order to combat pathogens, or as a treatment for cancer.

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Patent Owner(s)

  • STATENS SERUM INSTITUT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Agger, Else Marie Copenhagen S, DK 5 7
Andersen, Peter Brønshøj, DK 73 970
Olsen, Anja Søborg, DK 5 7
Rosenkrands, Ida Værløse, DK 16 112

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