Methods for Detecting Tumor Origin Based on MUC1, MUC2, and CK-17 Expression Levels
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United States of America Patent
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Issued Date -
Oct 20, 2011
app pub date -
Apr 15, 2011
filing date -
Apr 15, 2010
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Abstract
Methods and compositions for detecting tumor origin are disclosed. In certain embodiments, the origin is determined by detecting expression levels of pan-epithelial membrane mucin (MUC1), intestinal-type secretory mucin (MUC2), cytokeratin 17 (CK17), or a combination thereof. Also disclosed are methods for aiding in the determination of an appropriate course of treatment for a subject with a tumor, or for predicting a therapeutic outcome of a subject, based on the expression levels of MUC1, MUC2, CK17, or a combination thereof. Kits for use in each of these methods are also provided.
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