Flux Enhancement in Continuous Glucose Monitoring

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United States of America Patent

APP PUB NO 20110257497A1
SERIAL NO

12985229

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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One aspect of the invention is a method of in vivo monitoring of an individual's interstitial fluid glucose concentration comprising inserting a plurality of tissue piercing elements through a stratum corneum layer of an area of the individual's skin. The tissue piercing elements each comprise a distal end in fluid communication with interstitial fluid of the individual, and a proximal end in fluid communication with a sensing zone located outside of the patient's body. An interior space extends between the distal and proximal ends of the tissue piercing elements. A sensing fluid fills substantially the entire interior space and the sensing fluid concentration comprises a concentration of citrate in a buffer solution. The concentration of citrate may range from 100 mM to 200 mM, preferably 135-165 mM.

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Patent Owner(s)

Patent OwnerAddress
ARKAL MEDICAL INC46575 FREMONT BLVD FREMONT CA 94538

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jina, Arvind N San Jose, US 21 1506
Lee, Jonathan Sunnyvale, US 174 3392
Tamada, Janet Stanford, US 28 8408

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