Screening and treatment methods using IGS5 enzymes of the metalloprotease family

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United States of America Patent

PATENT NO 8389284
APP PUB NO 20110262930A1
SERIAL NO

13115569

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Abstract

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Polypeptides which are related to the neprilysin enzyme family and have zinc metalloprotease activities and are referred to as IGS5, polynucleotides encoding such polypeptides, vectors containing such polynucleotides, host cells containing such vectors, processes for producing such polypeptides and/or polynucleotides, screening methods for identifying compounds which stimulate or inhibit IGS5 polypeptides and/or polynucleotides, and the use of such polypeptides and/or polynucleotides in therapy of various dysfunctions, disorders or diseases, particularly cardiovascular diseases, metabolic diseases such as diabetes mellitus type II, and neurodegenerative disorders, such as Parkinson's Disease.

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Patent Owner(s)

  • ABBOTT HEALTHCARE PRODUCTS B.V.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Deleersnijder, Willy Vaalbeek, BE 14 25
Karimi-Nejad, Yasmin Hannover, DE 6 15
Weske, Michael Burgdorf, DE 24 55
Ziegler, Dieter Hemmingen, DE 33 153

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