Pharmaceutical Composition of Lyophilized Formulation and Preparation Method of the Same
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United States of America Patent
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Issued Date -
Oct 27, 2011
app pub date -
Dec 28, 2009
filing date -
Dec 29, 2008
priority date (Note) -
Abandoned
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Abstract
Disclosed is a pharmaceutical composition of a lyophilized formulation including a multiblock copolymer in which two or more ABA-type triblocks are covalently connected through biodegradable dicarboxylic linkage, wherein A represents a polyethylene oxide block and B represents a polypropylene oxide block, a polybutylene oxide block, or a block of copolymer of propylene oxide and butylene oxide, the multiblock copolymer being included in an amount of 1 to 7 wt % based on the total weight of solution prior to the lyophilized formulation. The composition is capable of reducing reconstitution time of a lyophilized sustained-release formulation.
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