METHODS FOR SYNTHESIZING KOTALANOL AND STEREOISOMERS AND ANALOGUES THEREOF, AND NOVEL COMPOUNDS PRODUCED THEREBY

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United States of America Patent

APP PUB NO 20110268822A1
SERIAL NO

12934898

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Abstract

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Compounds having the general formula (I): wherein X is S, Se or NH, and stereoisomers thereof, and de-O-sulfonated analogues of all of the foregoing, but excluding naturally occurring kotalanol and de-O-sulfonated kotalanol, and methods for synthesizing same. The compounds are useful as glycosidase inhibitors, and may be used in the treatment of diabetes. The synthetic compounds may also be used as standards in the calibration or grading of natural or herbal remedies produced from natural sources of glycosidase inhibitors such as kotalanol.

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Patent Owner(s)

Patent OwnerAddress
SIMON FRASER UNIVERSITY8888 UNIVERSITY DRIVE ROOM 2100 STRAND HALL BURNABY V5A 1S6

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kumarasamy, Jayakanthan Burnaby, CA 11 24
Mohan, Sankar Burnaby, CA 11 76
Nasi, Ravindranath Ottawa, CA 4 21
Pinto, Brian Mario Coquitlam, CA 5 6

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