BETA-SECRETASE ENZYME COMPOSITIONS AND METHODS
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United States of America Patent
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Issued Date -
Nov 17, 2011
app pub date -
Mar 23, 2011
filing date -
Dec 31, 1998
priority date (Note) -
Abandoned
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Abstract
Disclosed are various forms of an active, isolated β-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (β-APPwt and β-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate β-secretase. Inhibitors of β-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.
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