SILICA NANOPARTICLES POSTLOADED WITH PHOTOSENSITIZERS FOR DRUG DELIVERY IN PHOTODYNAMIC THERAPY
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United States of America Patent
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Issued Date -
Nov 24, 2011
app pub date -
Feb 19, 2009
filing date -
Feb 19, 2008
priority date (Note) -
Abandoned
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Abstract
A nanoparticle including a polysiloxane base having an exterior surface and having a photosensitizer at least partly exposed at its exterior surface, said photosensitizer being secured to the exterior surface by loading the photosensitizer onto the surface after formation of the polysiloxane base of the nanoparticle. The nanoparticle may have tumor targeting moieties and may be post loaded with cyanine dye. The nanoparticle preferably includes post loaded moieties providing at least two of tumor specificity, photodynamic properties and imaging capabilities and the photosensitizer is tagged with a radioisotope. A method for preparation of the nanoparticle is also provided.
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