Alzheimer's Disease Secretase, APP Substrates Therefor, and Uses Therefor
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United States of America Patent
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Issued Date -
Dec 1, 2011
app pub date -
May 20, 2011
filing date -
Sep 24, 1998
priority date (Note) -
Abandoned
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Abstract
The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
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