METHODS AND COMPOSITIONS FOR ASSESSING AND TREATING METASTASIS, METASTATIC CANCER, AND POTENTIAL FOR METASTASIS
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United States of America Patent
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Issued Date -
Dec 8, 2011
app pub date -
Jun 6, 2011
filing date -
Jun 4, 2010
priority date (Note) -
Abandoned
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Abstract
Disclosed are methods, compounds, and compositions for detection, diagnosis, prognosis, monitoring, treatment, monitoring treatment, and selecting treatment of cancer and metastasis, and for identifying compounds and compositions for such uses. For example, disclosed are methods, compounds, and compositions for detecting a risk of metastasis of cancer in a subject, treating a subject at risk of metastasis of cancer, identifying an inhibitor of HIF1α:FoxA2 function or complex formation, detecting a risk of neuroendocrine differentiation (NED)-associated cancer, determining a prognosis of a cancer, determining a treatment for a cancer, monitoring or determining the effect of treatment of a NED-associated cancer, treating NED-associated cancer, identifying an inhibitor of HIF1α:FoxA2 complex formation, detecting neuroendocrine differentiation (NED)-associated cancer, monitoring the risk of metastasis of cancer in a subject, and treating NED-associated cancer.
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