METHODS AND COMPOSITIONS TO ENHANCE VACCINE EFFICACY BY REPROGRAMMING REGULATORY T CELLS
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United States of America Patent
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Issued Date -
Dec 15, 2011
app pub date -
Apr 13, 2011
filing date -
Oct 21, 2005
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Abandoned
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Abstract
T cell activation and anti-tumor efficacy. Thus, Tregs in tumor-draining LNs can be actively re-programmed in vitro and in vivo into T-helper cells, without the need for physical depletion, and IDO serves as a key regulator of this critical conversion.
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