Compositions and Methods for Identifying Substrate Specificity of Inhibitors of Gamma Secretase
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United States of America Patent
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Issued Date -
Dec 15, 2011
app pub date -
Mar 8, 2011
filing date -
Jul 13, 2007
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Abstract
The invention provides assays and methods for determining the substrate specificity of gamma secretase inhibitors and for identifying substrate-selective (and substrate isoform-selective) inhibitors of gamma secretase. The invention provides assays and methods for determining whether a compound inhibits gamma secretase in a site specific or substrate specific manner. The invention provides isolated polypeptide sequences comprising modified gamma secretase substrates, and polynucleotide sequences encoding the polypeptide sequences. The invention also provides compounds that inhibit gamma secretase, pharmaceutical compositions comprising such compounds, and methods of treating Alzheimer's disease using such compounds.
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