DPYD GENE VARIANTS AND USE THEREOF
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United States of America Patent
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app pub date -
May 10, 2011
filing date -
Jun 23, 2006
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Abandoned
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Abstract
Variants in DPYD gene are disclosed which can result in abnormal synthesis of DPD proteins and alteration of DPD activities. The invention provides methods for detecting the newly discovered genetic variants. The DPD genetic variants of the invention can be used as biomarkers in predicting toxicity to 5-FU and other drugs metabolized by the DPD enzyme.
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