Method for Evaluating Immunosuppression
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United States of America Patent
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Issued Date -
Dec 22, 2011
app pub date -
Nov 11, 2009
filing date -
Nov 11, 2008
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Provided is a method for determining immunosuppression in an individual. The method entails obtaining a sample of blood from an individual, contacting cells in the blood sample with an activating agent to obtain activated cells, measuring the amount of nuclear NFkB in the activated cells, and comparing the amount of nuclear NFkB in the activated cells to a control. An amount of nuclear NFkB that is higher than the control is considered to be indicative of insufficient immunosuppression in the individual. An amount of nuclear NFkB that is lower than the control is considered to he indicative of excessive immunosuppression in the individual. An amount of nuclear NFkB that is the same as the control is considered to be indicative of an appropriate amount of immunosuppression in the individual.
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