Conjugates of a Lysosomal Enzyme Moiety and a Water Soluble Polymer
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United States of America Patent
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Dec 29, 2011
app pub date -
Jan 12, 2010
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Jan 12, 2009
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Abstract
Conjugates of a lysosomal enzyme moiety and one or more non-peptidic water soluble polymers are provided. Typically, the non-peptidic water soluble polymer is a poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising such conjugates, methods of making the conjugates, and methods of administering the compositions to a patient, e.g., for treatment of a lysosomal storage disease.
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