USE OF BUFFERS FOR RADIONUCLIDE COMPLEXATION
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United States of America Patent
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Issued Date -
Jan 12, 2012
app pub date -
Feb 11, 2010
filing date -
Feb 13, 2009
priority date (Note) -
Abandoned
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Abstract
The present invention relates to a method for complexation of a chelate with a radionuclide, advantageously gallium, the complexation being carried out advantageously at ambient temperature without heating, by adding the radionuclide to the chelate in a buffer solution, the buffer of this solution comprising between two and five functions for coordination with the radionuclide, each coordination function being independently chosen from a carboxylic acid function and a hydroxyl function, on the condition that the buffer comprises at least one carboxylic acid function and at most two carboxylic acid functions. It also relates to the injectable solution obtained.
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