US Patent Application No: 2012/0009,130

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Viral Therapy and Prophylaxis Using Nanotechnology Delivery Techniques

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Abstract

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The present disclosure provides compositions and methods of enhancing resistance to viral infections through targeted delivery of 5′PPP negative stranded siRNA via nanoparticles, specifically gold nanorods. The 5′PPP activates type I interferon through the signaling cascade providing a novel therapeutic and prophylactic for seasonal and pandemic influenza. The technology described herein also extends the findings to the use of nanoparticles for delivery of genetic material including but not limited to siRNA and microRNA to accomplish targeted nanoparticle based gene therapy.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
NANOAXISWILLIAMSVILLE, NY0
NANOAXIS, LLCCLARENCE, NY, US0

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chakravarthy, Krishnan - 9 1
Knight, Paul Bracknell, GB 16 169
Sambhara, Suryaprakash Markham, CA 15 35

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Klinische Pharmakologie (1)
* 2010/0178,272 STRUCTURE AND USE OF 5'PHOSPHATE OLIGONUCLEOTIDES 0 2007
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (1)
* 2008/0213,377 Delivery of Nanoparticles and/or Agents to Cells 37 2007
* Cited By Examiner

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