Tuberculosis TB vaccine to prevent reactivation
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United States of America Patent
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Jul 7, 2015
Grant Date -
Feb 16, 2012
app pub date -
Apr 23, 2010
filing date -
Apr 24, 2009
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Abstract
The present invention discloses a vaccine or immunogenic composition that can be administered to latently infected individuals to prevent reactivation of latent tuberculosis infection caused by species of the tuberculosis complex microorganisms (Mycobacterium tuberculosis, M. bovis, M. africanum). The invention is base on a number of M. tuberculosis derived proteins and protein fragments which are constitutively expressed in different stages of the infection. The invention is directed to the use of these polypeptides, immunologically active fragments thereof and the genes encoding them for immunological compositions such as vaccines.
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