p16 MEDIATED REGULATION OF NMDA RECEPTORS

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United States of America Patent

APP PUB NO 20120046446A1
SERIAL NO

13209302

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Discovered is a novel protein and variants thereof whose activity at the NMDA receptor causes an increased efflux of calcium ions through the channel of said receptor. This activity is downregulated by the NR3A subunit of NMDA. Also discovered are the nucleic acid sequences encoding said novel protein and variants thereof. The discovery is useful for the diagnosing of NMDA receptor dysregulation and the treatment of NMDA receptor dysregulation related disorders. In addition, the discovery is useful for the further discovery of modulators affecting the activity of the novel protein and variants thereof at the NMDA receptor.

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Patent Owner(s)

Patent OwnerAddress
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTELA JOLLA CA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Nakanishi, Nobuki Solana Beach, US 3 42
Tong, Gang San Diego, US 9 58
Tu, Shichun San Diego, US 4 43

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