ONE-POT SYNTHESIS OF LINEAR-LIKE POLYETHYLENIMINE FOR INTRACELLULAR IMAGING AND NUCLEIC ACID DELIVERY
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United States of America Patent
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Issued Date -
Mar 1, 2012
app pub date -
Aug 26, 2010
filing date -
Aug 26, 2010
priority date (Note) -
Abandoned
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Abstract
A method of synthesizing polyethyleneimine with a substantially linear backbone is disclosed. The method comprises exposing ethylenediamine dissolved in a solution to electromagnetic radiation for a sufficient time to polymerize the ethylenediamine and thereby resulting in formation of polyethylenimine with a substantially linear backbone in the solution. A method of synthesizing a homopolymer with a substantially linear backbone is also disclosed. In addition, a composition comprising polyethylenimine synthesized from the aforementioned method is disclosed, in which the polyethylenimine comprises a backbone conformation that is substantially linear and has a distribution of molecular weights (MW) ranging from 1 kDa to 200 kDa; and the polyethyleneimine has no cytotoxicity at a concentration of 12 μg/ml.
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