HIV-1-C RESISTANCE MONITORING
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United States of America Patent
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Issued Date -
Mar 15, 2012
app pub date -
May 11, 2010
filing date -
May 12, 2009
priority date (Note) -
Abandoned
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Abstract
The present invention relates to methods for the evaluation of HIV-1 Subtype C (HIV-1-C) treatment. The methods are based on evaluating molecular events at the HIV-1-C gag-protease-reverse transcriptase (GPRT) resulting in altered therapeutic efficacy of investigated anti-retroviral compounds. The methods rely on providing HIV-1-C GPRT RNA and evaluating a treatment either through genotyping or phenotyping methods. Said methods may find a use in the field of diagnostics, drug screening, pharmacogenetics and drug development.
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