Antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
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United States of America Patent
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Dec 11, 2012
Grant Date -
Mar 29, 2012
app pub date -
Oct 10, 2011
filing date -
May 2, 2000
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Abstract
An antibody of the invention interacts with human DR5 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-DR5 antibodies have been elucidated and vectors and cells containing and expressing these sequences have been generated. Methods and uses for the antibodies are detailed including treatment of apoptosis-related disease and treatment of dysregulated cell growth.
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