STABILIZED IMMUNOGLOBULIN CONSTANT DOMAINS
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United States of America Patent
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Issued Date -
Apr 19, 2012
app pub date -
Jul 1, 2010
filing date -
Jul 9, 2009
priority date (Note) -
Abandoned
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Abstract
The invention refers to a multidomain modular antibody comprising at least one constant antibody domain, which is mutated to form an artificial disulfide bridge by introducing at least one Cys residue into the amino acid sequence through mutagenesis of said constant domain to obtain an intra-domain or inter-domain disulfide bridge within the framework region, libraries based on such antibodies and methods of producing.
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