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United States of America Patent

APP PUB NO 20120100530A1





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The invention relates to constructs comprising a nucleic acid binding protein and a surface. At least one native accessible cysteine residue is removed from the binding protein. The binding protein is attached to the surface via one or more accessible cysteine residues. The removal of other accessible cysteine residues from the protein allows control attachment to the surface. The constructs can be used to generate transmembrane pores having a nucleic acid binding protein attached thereto. Such pores are particularly useful for sequencing nucleic acids. The enzyme handles the nucleic acid in such a way that the pore can detect each of its component nucleotides by stochastic sensing.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
Oxford Nanopore Technologies Ltd.KIDLINGTON, GB17

International Classification(s)


Inventor Name Address # of filed Patents Total Citations
Jayasinghe, Lakmal Oxford, GB 20 128
Knaggs, Michael Oxford, GB 14 108
Mckeown, Brian Oxon, GB 13 83
Milton, John Oxford, GB 40 873
Moysey, Ruth Oxford, GB 10 55
White, James Oxford, GB 96 747

Cited Art Landscape

Patent Info (Count) # Cites Year
Oxford Nanopore Technologies Ltd. (1)
* 2011/0229,877 ENZYME-PORE CONSTRUCTS 13 2009
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
Other [Check patent profile for assignment information] (2)
9957560 Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores 0 2012
9995728 Quadruplex method 0 2013
Oxford Nanopore Technologies Ltd. (4)
9751915 Mutant pores 0 2012
9777049 Mutant lysenin pores 0 2013
9551023 Sample preparation method 0 2013
9885078 Enzyme-pore constructs 0 2014
9732381 Method for sequencing a heteropolymeric target nucleic acid sequence 0 2010
9562887 Methods of enhancing translocation of charged analytes through transmembrane protein pores 0 2014
* Cited By Examiner