Systems for bioagent indentification

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 9194877
APP PUB NO 20120115213A1
SERIAL NO

12837191

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

The present invention provides systems and methods for analysis of samples, particularly biological and environmental sample to detect biomolecules of interest contained therein. A variety of system components are described herein, including, but not limited to, components for sample handling, mixing of materials, sample processing, transfer of materials, and analysis of materials. The invention further provides mechanisms for combining and integrating the different components and for housing, moving, and storing system components or the system as a whole. The systems may include any one or more or all of these components. The system finds particular use when employed for analysis of nucleic acid molecule using mass spectrometry, however, the invention is not limited such specific uses.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
IBIS BIOSCIENCES, INC.CARLSBAD, CA81

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bare, Rex O Lake Forest, US 108 3565
Bergold, Ronald K Misson Viejo, US 8 97
Drader, Jared J Carlsbad, US 35 291
Gleason, Paul J Laguna Niguel, US 16 144
Gutierrez, Jose R San Marcos, US 24 98
Hannis, James C Vista, US 21 347
Hofstadler, Steven A Vista, US 111 2259
Miller, Robert D Costa Mesa, US 116 1506
Nathanson, Jared Misson Viejo, US 8 27
Oberkramer, Kevin S Placentia, US 4 16
Smith, Jeffrey C Irvine, US 92 4084

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (13)
5504327 Electrospray ionization source and method for mass spectrometric analysis 80 1993
5745751 Civil site information system 82 1996
5822824 Mountable washing device 67 1996
6146144 Rug hooking kit and method for handicapped 74 1999
2004/0038,206 Method for high throughput assay of genetic analysis 75 2001
* 2002/0127,727 Structure and method for performing a determination of an item of interest in a sample 12 2002
2004/0038,208 Novel human phosphodiesterase IV isozymes 15 2002
2004/0023,207 Assays for drug discovery based on microcompetition with a foreign polynucleotide 26 2002
2003/0101,172 Tiered and content based database searching 16 2003
2003/0203,398 Nucleic acid fragments for the identification of bacteria in industrial wastewater bioreactors 15 2003
2005/0250,125 Method for conducting pharmacogenomics-based studies 61 2004
2009/0239,224 Methods for identifying bioagents 44 2008
2010/0145,626 Systems for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy 53 2009
 
RAMOT AT TEL AVIV UNIVERSITY LTD. (1)
2004/0101,809 Device, method and materials for mobilizing substances into dentinal tubules in root canal treatment 66 2003
 
GENETRACE SYSTEMS (4)
5864137 Mass spectrometer 123 1996
5965363 Methods of preparing nucleic acids for mass spectrometric analysis 129 1996
6051378 Methods of screening nucleic acids using mass spectrometry 99 1997
6566055 Methods of preparing nucleic acids for mass spectrometric analysis 91 1998
 
MEDICAL TACTILE, INC. (1)
6063031 Diagnosis and treatment of tissue with instruments 72 1997
 
OXFORD GENE TECHNOLOGY IP LIMITED (1)
5770367 Tag reagent and assay method 210 1996
 
GE HEALTHCARE BIO-SCIENCES CORP.;PATENT DEPARTMENT (1)
5576204 .phi.29 DNA polymerase 131 1993
 
PE CORPORATION (NY) (1)
2003/0039,976 Methods for base counting 62 2001
 
GENE TRACE SYSTEMS, INC. (1)
6265716 Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry 89 2000
 
BRUKER DALTONIK GMBH (1)
6836742 Method and apparatus for producing mass spectrometer spectra with reduced electronic noise 64 2002
 
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (1)
6110710 Sequence modification of oligonucleotide primers to manipulate non-templated nucleotide addition 61 1998
 
UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (1)
6419932 Antigen of hybrid M protein and carrier for Group A streptococccal vaccine 80 1997
 
Edge Biosystems, Inc. (1)
2002/0042,506 Ion exchange method for DNA purification 26 2001
 
Wakunaga Seiyaku Kabushiki Kaisha (1)
5702895 Method and kit for detecting methicillin-resistant Staphylococcus aureus 111 1996
 
SIGMA-ALDRICH CO. (1)
2005/0026,147 Methods and compositions for amplification of dna 64 2003
 
DECODE GENETICS EHF. (1)
2003/0186,247 Method for desalting nucleic acids 58 2002
 
CANCER RESEARCH TECHNOLOGY LIMITED (1)
6268129 Method of nucleic acid analysis 66 1997
 
BRUKER NANO, INC. (1)
6265718 Scanning probe microscope with scan correction 67 2000
 
SEQUENOM, INC. (7)
6436635 Solid phase sequencing of double-stranded nucleic acids 103 1996
2002/0042,112 DNA DIAGNOSTICS BASED ON MASS SPECTROMETRY 111 1998
2003/0129,589 DNA DIAGNOSTICS BASED ON MASS SPECTROMETRY 96 1999
2003/0113,745 Methods of screening nucleic acids using mass spectrometry 73 2002
2003/0220,844 Method and system for purchasing genetic data 77 2002
2009/0023,150 DNA Diagnostics Based on Mass Spectrometry 55 2008
2009/0042,203 Mass Spectrometric Methods for Detecting Mutations in a Target Nucleic Acid 62 2008
 
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. (1)
7022835 Method for binding nucleic acids to a solid phase 61 2000
 
MICROMASS UK LIMITED (1)
6906319 Mass spectrometer 92 2002
 
TAXON BIOSCIENCES, INC. (1)
6613520 Methods for the survey and genetic analysis of populations 76 2001
 
GOLDMAN SACHS BANK USA (1)
2005/0130,216 Molecular torches and their use under strand displacement conditions 24 2005
 
UNIVERSITY OF VIRGINIA (2)
5366896 Robotically operated laboratory system 302 1991
6055487 Interactive remote sample analysis system 196 1997
 
NIKON CORPORATION (1)
6266131 Exposure apparatus 52 1999
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (2)
5143905 Method and means for extending the host range of insecticidal proteins 64 1990
5747251 Polymerase chain reaction assays to determine the presence and concentration of a target nucleic acid in a sample 68 1995
 
MONOGRAM BIOSCIENCES, INC. (1)
6007690 Integrated microfluidic devices 324 1997
 
PERSEPTIVE BIOSYSTEMS, INC. (1)
5015845 Electrospray method for mass spectrometry 163 1990
 
E. I. DU PONT DE NEMOURS AND COMPANY (1)
5753467 Method for the identification of microorganisms by the utilization of directed and arbitrary DNA amplification 68 1996
 
UNIVERSITY OF IDAHO (1)
2006/0172,330 Categorization of microbial communities 61 2006
 
THE UNIVERSITY OF BRITISH COLUMBIA (1)
6856914 Method, apparatus, media and signals for identifying associated cell signaling proteins 58 2000
 
The Board of Trustees of the University of Illinois (1)
6563025 Nucleotide sequences encoding anthranilate synthase 62 1999
 
PRESSURE BIOSCIENCES, INC. (1)
6274726 Pressure-enhanced extraction and purification 82 1998
 
HEALTHSHORE, INC. (1)
2005/0065,813 Online medical evaluation system 164 2003
 
CONAGRA GROCERY PRODUCTS COMPANY (1)
6468743 PCR techniques for detecting microbial contaminants in foodstuffs 72 1999
 
PIONEER HI-BRED INTERNATIONAL, INC. (1)
2003/0084,483 Methods and means for modification of plant characteristics 24 2002
 
UT-BATTELLE, LLC (1)
2004/0111,221 Oligonucleotide probes for genosensor chips 62 2003
 
NANOTHERAPEUTICS, INC. (1)
5753489 Method for producing viruses and vaccines in serum-free culture 79 1995
 
BRUKER-FRANZEN ANALYTIK GMBH (3)
5504329 Method of ionizing atoms or molecules by electrospraying 83 1995
5608217 Electrospraying method for mass spectrometric analysis 89 1995
6180372 Method and devices for extremely fast DNA replication by polymerase chain reactions (PCR) 174 1998
 
GENEOHM SCIENCES CANADA INC. (1)
5994066 Species-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories 163 1996
 
SGF SANTE INC (1)
2002/0055,101 SPECIFIC AND UNIVERSAL PROBES AND AMPLIFICATION PRIMERS TO RAPIDLY DETECT AND IDENTIFY COMMON BACTERIAL PATHOGENS AND ANTIBIOTIC RESISTANCE GENES FROM CLINICAL SPECIMENS FOR ROUTINE DIAGNOSIS IN MICROBIOLOGY LABORATORIES 74 1999
 
LIFE TECHNOLOGIES CORPORATION (1)
6914137 Isolation of nucleic acids 147 2000
 
DUKE UNIVERSITY (2)
5683869 Method of nucleic acid sequencing 77 1994
2003/0064,483 Method of nucleic acid sequencing 29 2001
 
MERCK & CO., INC. (1)
2004/0029,129 Identification of essential genes in microorganisms 201 2002
 
MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN (1)
2001/0039,263 Chimeric oligonucleotides and the use thereof 54 2001
 
TRANSGENOMIC, INC. (1)
2004/0191,769 Methods, compositions, and kits for mutation detection in mitochondrial DNA 59 2002
 
ABBOTT LABORATORIES (1)
2009/0117,620 AUTOMATED ANALYZER FOR CLINICAL LABORATORY 39 2008
 
JACKSON, GEORGE W. (1)
2005/0142,584 Microbial identification based on the overall composition of characteristic oligonucleotides 57 2004
 
Waters Corporation (1)
5828062 Ionization electrospray apparatus for mass spectrometry 71 1997
 
PICIS, INC. (1)
7024370 Methods and apparatus for early detection of health-related events in a population 73 2002
 
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (1)
5213961 Accurate quantitation of RNA and DNA by competetitive polymerase chain reaction 93 1989
 
ISIS PHARMACEUTICALS, INC. (15)
5484908 Oligonucleotides containing 5-propynyl pyrimidines 285 1991
5645985 Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines 255 1992
5502177 Pyrimidine derivatives for labeled binding partners 266 1993
5686242 Determination of oligonucleotides for therapeutics, diagnostics and research reagents 95 1994
6005096 Pyrimidine derivatives 184 1995
5763588 Pyrimidine derivatives for labeled binding partners 177 1995
5830653 Methods of using oligomers containing modified pyrimidines 241 1995
6028183 Pyrimidine derivatives and oligonucleotides containing same 120 1997
6007992 Pyrimidine derivatives for labeled binding partners 110 1997
7321828 System of components for preparing oligonucleotides 107 1998
6221587 Identification of molecular interaction sites in RNA for novel drug discovery 126 1998
6428956 Mass spectrometric methods for biomolecular screening 81 1998
6875593 Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines 61 2002
2003/0228,597 Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation 287 2003
2004/0014,957 Oligonucleotides having modified nucleoside units 97 2003
 
GENTEGRA LLC (1)
6153389 DNA additives as a mechanism for unambiguously marking biological samples 81 1999
 
SRI INTERNATIONAL (2)
5700642 Oligonucleotide sizing using immobilized cleavable primers 241 1995
5830655 Oligonucleotide sizing using cleavable primers 183 1996
 
MOSAIC TECHNOLOGIES, INC. (1)
6238927 Reverse displacement assay for detection of nucleic acid sequences 84 1999
 
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (1)
6268131 Mass spectrometric methods for sequencing nucleic acids 130 1997
 
NORTHWESTERN UNIVERSITY (1)
6432651 Method to detect and analyze tight-binding ligands in complex biological samples using capillary electrophoresis and mass spectrometry 63 2001
 
LARGE SCALE PROTEOMICS CORPORATION (1)
6479239 Detection and characterization of microorganisms 66 2000
 
BIO MERIEUX (1)
5849901 DNA fragments of mycobacteria, amplification primers hybridization probes, reagents and method for the detection of mycobacteria 75 1996
 
CORNING INCORPORATED (1)
2003/0148,284 Solid phase detection of nucleic acid molecules 62 2001
 
MARC OUELLETTE (1)
6001564 Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories 141 1995
 
VIROLOGIC, INC. (1)
2002/0150,927 Methods for detecting a plurality of analytes by mass spectrometry 27 2001
 
PharmacoGenetics, Ltd. (1)
2003/0017,487 Method for detecting single nucleotide polymorphisms (SNP'S) and point mutations 28 2002
 
SCIENCE APPLICATIONS INTERNATIONAL CORPORATION (1)
2004/0209,260 Methods and apparatus for genetic evaluation 54 2003
 
MDS INC. (1)
5625184 Time-of-flight mass spectrometry analysis of biomolecules 164 1995
 
Gene Tec Corporation (2)
5451500 Device for processing biological specimens for analysis of nucleic acids 164 1992
5436129 Process for specimen handling for analysis of nucleic acids 189 1993
 
WAYNE STATE UNIVERSITY (1)
5580733 Vaporization and sequencing of nucleic acids 153 1994
 
Gene Shears Pty. Limited (1)
6277634 Optimized minizymes and miniribozymes and uses thereof 65 1998
 
BECTON, DICKINSON AND COMPANY (2)
6682889 Amplification and detection of organisms of the Chlamydiaceae family 66 2000
6586584 Sequences and methods for detection of Hepatitis C virus 58 2001
 
MEDICAL RESEARCH COUNCIL (1)
6239159 Nucleoside analogues 105 1999
 
Incyte Pharmaceuticals, Inc. (4)
5876936 Nucleic acid sequencing with solid phase capturable terminators 97 1997
6303297 Database for storage and analysis of full-length sequences 99 1997
6046005 Nucleic acid sequencing with solid phase capturable terminators comprising a cleavable linking group 172 1998
6389428 System and method for a precompiled database for biomolecular sequence information 88 2001
 
PNA DIAGNOSTICS A/S (1)
6235476 Process for detecting nucleic acids by mass determination 77 1999
 
AFFYMETRIX, INC. (2)
5856174 Integrated nucleic acid diagnostic device 643 1996
2003/0104,410 Human microarray 76 2002
 
Incyte Genomics, Inc. (1)
6553317 Relational database and system for storing information relating to biomolecular sequences and reagents 95 1998
 
BAYLOR COLLEGE OF MEDICINE (1)
5523217 Fingerprinting bacterial strains using repetitive DNA sequence amplification 91 1994
 
SIRNA THERAPEUTICS, INC. (1)
2003/0190,635 RNA interference mediated treatment of Alzheimer's disease using short interfering RNA 151 2002
 
NATIONAL INSTITUTE OF TECHNOLOGY AND EVALUATION (1)
2003/0119,018 Novel polynucleotides 71 2002
 
UROCOR, INC. (1)
2003/0050,470 Biomarkers and targets for diagnosis, prognosis and management of prostate disease, bladder and breast cancer 69 2001
 
PALM COMPUTING, INC. (2)
5727202 Method and apparatus for synchronizing information on two different computer systems 565 1995
5832489 Method and apparatus for synchronizing information on two different computer systems 293 1997
 
III HOLDINGS 1, LLC (1)
6705530 Transparent/translucent financial transaction card 140 2003
 
WHATMAN LIMITED (1)
2003/0134,312 Methods and materials for detecting genetic material 25 2002
 
TRUSTEES OF BOSTON UNIVERSITY (3)
5503980 Positional sequencing by hybridization 252 1994
2002/0045,178 Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing 27 2001
2004/0081,993 Quantification of gene expression 83 2003
 
THE JOHNS HOPKINS UNIVERSITY (2)
6605433 Mitochondrial dosimeter 70 2000
2004/0005,555 Molecular diagnosis of bactermia 61 2001
 
BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (1)
2002/0187,490 Microbial identification chip based on DNA-DNA hybridization 53 2002
 
IBIS BIOSCIENCES, INC. (59)
2003/0027,135 Method for rapid detection and identification of bioagents 76 2001
7217510 Methods for providing bacterial bioagent characterizing information 70 2001
7108974 Method for rapid detection and identification of bioagents 71 2002
2003/0175,695 Method for rapid detection and identification of bioagents 73 2002
2003/0175,696 Method for rapid detection and identification of bioagents 72 2002
2003/0175,697 Method for rapid detection and identification of bioagents 73 2002
2003/0190,605 Methods for rapid detection and identification of bioagents for environmental testing 73 2002
2003/0225,529 Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent for environmental testing thereby 61 2002
2004/0121,309 Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues 61 2002
2004/0121,310 Methods for rapid detection and identification of bioagents in forensic studies 61 2002
2004/0121,311 Methods for rapid detection and identification of bioagents in livestock 61 2002
2004/0121,312 Methods for rapid detection and identification of the absence of bioagents 61 2002
2004/0121,313 Methods for rapid detection and identification of bioagents in organs for transplantation 62 2002
2004/0121,314 Methods for rapid detection and identification of bioagents in containers 61 2002
2004/0121,315 Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in containers thereby 61 2002
2004/0121,329 Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in blood, bodily fluids, and bodily tissues thereby 61 2002
2004/0121,335 Methods for rapid detection and identification of bioagents associated with host versus graft and graft versus host rejections 61 2002
2004/0121,340 Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent associated with host versus graft and graft versus host rejections thereby 61 2002
2004/0122,598 Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in food products and cosmetics thereby 61 2002
2004/0122,857 Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in forensic studies thereby 61 2002
2003/0167,133 Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby 61 2003
2003/0167,134 Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby 61 2003
2003/0187,588 Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby 61 2003
2003/0187,593 Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby 61 2003
2003/0228,571 Method for rapid detection and identification of viral bioagents 61 2003
2004/0110,169 Method for rapid detection and identification of bioagents 66 2003
2004/0202,997 Method for rapid detection and identification of bioagents 66 2003
2004/0117,129 Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby 61 2003
2005/0027,459 Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby 62 2003
7781162 Methods for rapid identification of pathogens in humans and animals 53 2003
7226739 Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations 72 2003
7255992 Methods for rapid detection and identification of bioagents for environmental and product testing 77 2003
7666588 Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy 51 2003
7718354 Methods for rapid identification of pathogens in humans and animals 52 2003
2004/0185,438 Methods of detection and notification of bioagent contamination 63 2004
2004/0253,619 Methods for rapid detection and identification of bacterial bioagents 54 2004
2004/0253,583 Methods for rapid detection and identification of viral bioagents 55 2004
2005/0266,397 Methods for identification of coronaviruses 57 2004
2005/0266,411 Methods for rapid forensic analysis of mitochondrial DNA 57 2004
2005/0130,196 Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture 57 2004
2009/0004,643 METHODS FOR CONCURRENT IDENTIFICATION AND QUANTIFICATION OF AN UNKNOWN BIOAGENT 60 2005
2006/0259,249 Rapid identification of microbial agents 70 2005
7312036 Compositions for use in identification of viral hemorrhagic fever viruses 67 2005
2008/0160,512 Method for rapid detection and identification of bioagents 48 2005
7741036 Method for rapid detection and identification of bioagents 58 2006
2006/0121,520 Method for rapid detection and identification of bioagents 52 2006
2006/0205,040 Compositions for use in identification of adventitious viruses 62 2006
2006/0240,412 Compositions for use in identification of adenoviruses 63 2006
2007/0218,467 Methods for rapid identification and quantitation of nucleic acid variants 49 2006
* 2007/0087,336 Compositions for use in identification of influenza viruses 4 2006
2008/0311,558 Methods For Rapid Identification Of Pathogens In Humans And Animals 54 2007
2009/0148,829 Methods For Rapid Identification Of Pathogens In Humans And Animals 46 2007
2009/0148,836 Method for Rapid Detection and Identification of Bioagents 40 2007
2009/0148,837 Method for Rapid Detection and Identification of Bioagents 45 2007
2009/0182,511 Methods For Rapid Forensic Analysis Of Mitochondrial DNA And Characterization Of Mitochondrial DNA Heteroplasmy 51 2007
2010/0184,035 METHODS FOR RAPID FORENSIC DNA ANALYSIS 50 2008
2009/0125,245 Methods For Rapid Forensic Analysis Of Mitochondrial DNA 45 2008
* 2010/0128,558 MIXING CARTRIDGES, MIXING STATIONS, AND RELATED KITS, SYSTEMS, AND METHODS 13 2009
2010/0070,194 METHODS FOR RAPID IDENTIFICATION AND QUANTITATION OF NUCLEIC ACID VARIANTS 46 2009
 
AGILENT TECHNOLOGIES, INC. (6)
5716825 Integrated nucleic acid analysis system for MALDI-TOF MS 269 1995
6312893 Methods and compositions for determining the sequence of nucleic acid molecules 186 1997
6074831 Partitioning of polymorphic DNAs 73 1998
6218118 Method and mixture reagents for analyzing the nucleotide sequence of nucleic acids by mass spectrometry 111 1998
6623928 Methods and compositions for determining the sequence of nucleic acid molecules 92 2001
6680476 Summed time-of-flight mass spectrometry utilizing thresholding to reduce noise 77 2002
 
PENFORD CORPORATION (1)
7349808 System and method for tracking and controlling infections 61 2000
 
Polymun Scientific Immunbiologische Forschung GmbH (1)
2004/0137,013 Live vaccine and method of manufacture 100 2003
 
PROMEGA CORPORATION (9)
6221598 Multiplex amplification of short tandem repeat loci 85 1999
6235480 Detection of nucleic acid hybrids 96 1999
6391551 Detection of nucleic acid hybrids 74 1999
6270973 Multiplex method for nucleic acid detection 76 1999
6270974 Exogenous nucleic acid detection 68 1999
6312902 Nucleic acid detection 81 1999
6277578 Deploymerization method for nucleic acid detection of an amplified nucleic acid target 75 1999
6268146 Analytical methods and materials for nucleic acid detection 104 1999
2003/0194,699 Multiplex method for nucleic acid detection 25 2001
 
CYBIO AG (1)
2006/0171,853 Tips for pipetting devices or dispensing devices 1 2006
 
NOVARTIS AG (1)
7390458 High throughput processing system and method of using 95 2001
 
CAMBREX BIO SCIENCE ROCKLAND, INC. (1)
5876938 Use of boron-containing polynucleotides as diagnostic agents 62 1997
 
GENPRIME (1)
2002/0168,630 Method and apparatus for prokaryotic and eukaryotic cell quantitation 30 2002
 
The United States of America as represented by the Secretary of Agriculture (1)
6261769 Intergenic spacer target sequence for detecting and distinguishing Chlamydial species or strains 65 1998
 
TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD. (1)
6266144 Stepper and scanner new exposure sequence with intra-field correction 86 1999
 
AVI BIOPHARMA, INC. (1)
6060246 Reagent and method for isolation and detection of selected nucleic acid sequences 78 1997
 
XZILLION GMBH & CO. (1)
6582916 Metal ion-binding mass markers for nucleic acids 60 2001
 
SCIMED LIFE SYSTEMS, INC. (1)
2006/0068,360 Single use fluid reservoir for an endoscope 23 2004
 
GEORGETOWN UNIVERSITY (1)
5814442 Internally controlled virion nucleic acid amplification reaction for quantitation of virion and virion nucleic acid 62 1994
 
QIAGEN GMBH (3)
6977148 Multiple displacement amplification 108 2001
2004/0126,764 Nucleic acid amplification 62 2002
2003/0228,613 Nucleic acid amplification 47 2003
 
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (1)
6783939 Alphavirus vectors and virosomes with modified HIV genes for use in vaccines 74 2001
 
EGENOMICS, INC. (2)
2002/0120,408 System and method for tracking and controlling infections 60 2002
2006/0020,391 Method for tracking and controlling infections 66 2004
 
AKZO NOBEL N.V. (1)
5834255 Quantification of nucleic acid 71 1995
 
GEN-PROBE INCORPORATED (5)
5288611 Method for detecting, identifying, and quantitating organisms and viruses 172 1992
5472843 Nucleic acid probes to Haemophilus influenzae 66 1994
5567587 Method for detecting, the presence and amount of prokaryotic organisms using specific rRNA subsequences as probes 81 1995
5641632 Method for preparing rRNA for hybridization with a probe 57 1995
6372424 Rapid detection and identification of pathogens 93 1995
 
CELERA CORPORATION (1)
5759771 Method of determining a genotype by comparing the nucleotide sequence of members of a gene family and kit therefor 65 1993
 
ORTHO-CLINICAL DIAGNOSTICS, INC. (1)
6638714 Oligonucleotide primers for efficient detection of hepatitis C virus (HCV) and methods of use thereof 63 2000
 
DIAGNOSTIC INFORMATION SYSTEMS COMPANY, INC. (1)
6018713 Integrated system and method for ordering and cumulative results reporting of medical tests 241 1998
 
KABUSHIKI KAISHA TOSHIBA (1)
2003/0104,699 Slurry for chemical mechanical polishing for copper and method of manufacturing semiconductor device using the slurry 24 2002
 
LENOVO INNOVATIONS LIMITED (HONG KONG) (1)
2005/0026,641 Mobile communicatiion system, mobile communication terminal, power control method used therefor, and program therefor 62 2004
 
PRIMAGEN HOLDING B.V. (1)
2003/0073,112 Universal nucleic acid amplification system for nucleic acids in a sample 27 2002
 
CIBA CORNING DIAGNOSTICS CORP. (2)
5763169 Nucleic acid probes for the detection and identification of fungi 76 1995
5707802 Nucleic acid probes for the detection and identification of fungi 110 1995
 
Keygene N.V. (1)
2003/0175,729 Method for generating oligonucleotides, in particular for the detection of amplified restriction fragments obtained using aflp 28 2003
 
PROTEOMETRICS, LLC (1)
6393367 Method for evaluating the quality of comparisons between experimental and theoretical mass data 75 2000
 
CORNELL UNIVERSITY (1)
6852487 Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays 157 1997
 
THERMO FINNIGAN LLC (1)
5072115 Interpretation of mass spectra of multiply charged ions of mixtures 92 1990
 
OSTEOTOOLS, LLC (1)
2004/0013,703 Bioabsorbable plugs containing drugs 38 2002
 
FUJI ELECTRIC CO., LTD. (1)
6906316 Semiconductor device module 60 2003
 
Bayer Aktiengesellschaft (1)
6015666 Rapid DNA test for detecting quinolone-resistant Staphylococcus aureus pathogens in clinical material 85 1995
 
EXIQON A/S (2)
6436640 Use of LNA in mass spectrometry 96 2000
2003/0224,377 Novel LNA compositions and uses thereof 50 2002
 
CABTECH, INC. (1)
2002/0006,611 COMPOSITIONS AND METHODS FOR DIFFERENTIATING AMONG SHIGELLA SPECIES AND SHIGELLA FROM E. COLI SPECIES 58 1998
 
GENETIC TECHNOLOGIES LIMITED (1)
5612179 Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes 91 1992
 
CEMV Bioteknik AB (1)
5712125 Competitive PCR for quantitation of DNA 66 1995
 
HIGH THROUGHPUT GENOMICS, INC. (1)
6458533 High throughput assay system for monitoring ESTs 98 1998
 
SIGRIS RESEARCH, INC. (1)
7476313 Apparatus for mixing magnetic particles 50 2006
 
Institut Pasteur (1)
5747246 Process for determining the quantity of a DNA fragment of interest by a method of enzymatic amplification of DNA 67 1994
 
Minolta Co., Ltd. (1)
5845174 Image forming apparatus equipped with cleaning device 67 1997
 
MINISTER OF DEFENCE, THE (1)
6800289 Strain of the western equine encephalitis virus 62 2001
 
ROGAN, PETER K. (1)
5849492 Method for rapid identification of prokaryotic and eukaryotic organisms 77 1996
 
SANDVIK AB (1)
2004/0023,209 Method for identifying microorganisms based on sequencing gene fragments 61 2002
 
HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP (1)
6061686 Updating a copy of a remote document stored in a local computer system 149 1997
 
CHIRON DIAGNOSTICS CORPORATION (1)
6180339 Nucleic acid probes for the detection and identification of fungi 76 1997
 
CURAGEN CORPORATION (2)
5871697 Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing 220 1995
5972693 Apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing 107 1996
 
CALIFORNIA INSTITUTE OF TECHNOLOGY (1)
2002/0137,057 Rapid, quantitative method for the mass spectrometric analysis of nucleic acids for gene expression and genotyping 25 2001
 
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (1)
6568055 Arbor clamping apparatus for boring and milling machines 52 2002
 
MOMENTUM HEALTHCARE LTD. (1)
6813615 Method and system for interpreting and validating experimental data with automated reasoning 71 2000
 
CONSORTIUM NATIONAL DE RECHERCHE EN GENOMIQUE (CNRG) (1)
2004/0038,234 Sample generation for genotyping by mass spectrometry 61 2003
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (1)
6994962 Methods of identifying point mutations in a genome 81 2000
 
CURIS, INC. (1)
5981190 Analysis of gene expression, methods and reagents therefor 89 1998
 
SAVIENT PHARMACEUTICALS, INC. (1)
5965383 Fibrin binding domain polypeptides and uses and methods of producing same 53 1995
 
UNIVERSITY OF ROCHESTER (1)
5639606 Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction 127 1994
 
SYNTRIX BIOSYSTEMS, INC. (1)
6159681 Light-mediated method and apparatus for the regional analysis of biologic material 97 1999
 
AGENA BIOSCIENCE, INC. (47)
5547835 DNA sequencing by mass spectrometry 320 1994
5622824 DNA sequencing by mass spectrometry via exonuclease degradation 236 1995
5605798 DNA diagnostic based on mass spectrometry 258 1995
5851765 DNA sequencing by mass spectrometry via exonuclease degradation 134 1995
5872003 DNA sequencing by mass spectrometry via exonuclease degradation 143 1995
5691141 DNA sequencing by mass spectrometry 215 1995
6225450 DNA sequencing by mass spectrometry 117 1995
6146854 Filtration processes, kits and devices for isolating plasmids 112 1995
5869242 Mass spectrometry to assess DNA sequence polymorphisms 167 1995
6043031 DNA diagnostics based on mass spectrometry 187 1996
6194144 DNA sequencing by mass spectrometry 130 1996
5928906 Process for direct sequencing during template amplification 210 1996
5777324 Method and apparatus for maldi analysis 160 1996
5900481 Bead linkers for immobilizing nucleic acids to solid supports 343 1996
6074823 DNA sequencing by mass spectrometry via exonuclease degradation 168 1996
6428955 DNA diagnostics based on mass spectrometry 95 1996
6024925 Systems and methods for preparing low volume analyte array elements 237 1997
7285422 Systems and methods for preparing and analyzing low volume analyte array elements 78 1997
6111251 Method and apparatus for MALDI analysis 146 1997
6133436 Beads bound to a solid support and to nucleic acids 257 1997
6104028 Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry 98 1998
6322970 Mass spectrometric detection of polypeptides 140 1998
6090558 DNA typing by mass spectrometry with polymorphic DNA repeat markers 138 1998
6140053 DNA sequencing by mass spectrometry via exonuclease degradation 188 1998
6197498 DNA diagnostics based on mass spectrometry 115 1999
6235478 DNA diagnostics based on mass spectrometry 106 1999
6258538 DNA diagnostics based on mass spectrometry 118 1999
6277573 DNA diagnostics based on mass spectrometry 109 1999
6558902 Infrared matrix-assisted laser desorption/ionization mass spectrometric analysis of macromolecules 130 1999
6706530 IR-MALDI mass spectrometry of nucleic acids using liquid matrices 68 1999
6268144 DNA diagnostics based on mass spectrometry 174 1999
6221601 DNA diagnostics based on mass spectrometry 108 1999
6423966 Method and apparatus for maldi analysis 97 2000
6300076 DNA diagnostics based on mass spectrometry 115 2000
6221605 DNA diagnostics based on mass spectrometry 106 2000
6468748 Methods of screening nucleic acids using volatile salts in mass spectrometry 86 2000
6238871 DNA sequences by mass spectrometry 113 2000
6485913 Systems and methods for performing reactions in an unsealed environment 87 2000
7198893 DNA diagnostics based on mass spectrometry 70 2000
6475736 Methods for genetic analysis of DNA using biased amplification of polymorphic sites 95 2000
6602662 DNA diagnostics based on mass spectrometry 91 2000
6500621 DNA diagnostics based on mass spectrometry 89 2001
6589485 Solid support for mass spectrometry 90 2001
6610492 Base-modified nucleotides and cleavage of polynucleotides incorporating them 69 2002
7419787 Mass spectrometric methods for detecting mutations in a target nucleic acid 64 2006
7501251 DNA diagnostics based on mass spectrometry 66 2006
2009/0092,977 MASS SPECTROMETRIC METHODS FOR DETECTING MUTATIONS IN A TARGET NUCLEIC ACID 62 2008
 
HEALTHWAYS SC, LLC (1)
6475143 Automated diagnostic system and method including encoding patient data 126 2001
 
APPLIED BIOSYSTEMS, LLC (3)
5527675 Method for degradation and sequencing of polymers which sequentially eliminate terminal residues 122 1993
5866429 Precision and accuracy of anion-exchange separation of nucleic acids 63 1995
5885775 Methods for determining sequences information in polynucleotides using mass spectrometry 191 1996
 
CITY OF HOPE (1)
5981176 Method of detecting and discriminating between nucleic acid sequences 201 1994
 
SINGULEX, INC. (1)
2009/0171,590 System and Methods for Sample Analysis 19 2008
 
ROCHE MOLECULAR SYSTEMS, INC. (6)
4683202 Process for amplifying nucleic acid sequences 3781 1985
4683195 Process for amplifying, detecting, and/or-cloning nucleic acid sequences 3259 1986
4965188 Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme 1336 1987
5219727 Quantitation of nucleic acids using the polymerase chain reaction 171 1989
5476774 Quantitation of nucleic acids using the polymerase chain reaction 132 1993
5527669 Methods, primers and probes for detection of hepatitis C and novel variants 101 1994
 
GENERAL ELECTRIC COMPANY (1)
2004/0117,354 Process for tagging and measuring quality 54 2002
 
CAPSTAN AG SYSTEMS, INC. (1)
7502665 Networked diagnostic and control system for dispensing apparatus 12 2005
 
ESOTERIX GENETIC LABORATORIES, LLC (1)
6475738 Methods for detecting mutations using primer extension for detecting disease 66 2001
 
MILLENNIUM PHARMACEUTICALS, INC. (1)
2003/0148,281 65499 and 58875, novel seven transmembrane receptors and uses thereof 51 2001
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (1)
6453244 Detection of polymorphisms by denaturing high-performance liquid chromatography 73 2000
 
GLAXO GROUP LIMITED (1)
5928905 End-complementary polymerase reaction 230 1996
 
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (1)
5849497 Specific inhibition of the polymerase chain reaction using a non-extendable oligonucleotide blocker 108 1997
 
ASTRA AKTLEBOLAG (1)
5830853 Systemic administration of a therapeutic preparation 143 1996
 
MITOKOR (1)
5976798 Methods for detecting mitochondrial mutations diagnostic for Alzheimer's disease and methods for determining heteroplasmy of mitochondrial nucleic acid 98 1997
 
United States of America (1)
2002/0138,210 Microbial identification databases 33 2001
 
SIEMENS HEALTHCARE DIAGNOSTICS INC. (1)
6214555 Method compositions and kit for detection 82 1999
 
New Japan Chemical Co., Ltd. (1)
6187842 Sugar compounds, gelling agents, gelling agent compositions processes for the preparation of them, and gel compositions 67 1999
 
LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (1)
2004/0038,385 System for autonomous monitoring of bioagents 120 2003
 
LOS ALAMOS NATIONAL SECURITY, LLC (1)
6613509 Determination of base (nucleotide) composition in DNA oligomers by mass spectrometry 70 1999
 
PRESIDENT AND FELLOWS OF HARVARD COLLEGE (1)
2003/0113,738 Evolving new molecular function 35 2002
 
APPLIED BIOSYSTEMS DIVISION (1)
6054278 Ribosomal RNA gene polymorphism based microorganism identification 63 1998
 
RAPIGENE, INC. (1)
6361940 Compositions and methods for enhancing hybridization and priming specificity 116 1998
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

  • No Forward Cites to Display

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
3.5 Year Payment $1600.00 $800.00 $400.00 May 24, 2019
7.5 Year Payment $3600.00 $1800.00 $900.00 May 24, 2023
11.5 Year Payment $7400.00 $3700.00 $1850.00 May 24, 2027
Fee Large entity fee small entity fee micro entity fee
Surcharge - 3.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00